beta-sarcoglycan; beta-SG; 43 kD dystrophin-associated glycoprotein; 43DAG; A3b (SGCB)

Function

• component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton & the extracellular matrix
• disulfide bonds are present
• cross-link to form 2 major subcomplexes:
  • one consisting of SGCB, SGCD & SGCG
  • the other consisting of SGCB & SGCD
• association between SGCB & SGCG is particularly strong
• SGCA is loosely associated with the other sarcoglycans

Structure

• belongs to the sarcoglycan beta/delta/gamma/zeta family

Compartment

• cell membrane, sarcolemma; single-pass type 2 membrane protein (putative)
• cytoplasm, cytoskeleton

Expression

• highest expression in heart & skeletal muscle
• low expression in brain, kidney, placenta, pancreas & lung
• high expression in fetal brain. also found in fetal lung, kidney & liver

Pathology

• defects in SGCB are the cause of limb-girdle muscular dystrophy type 2E

More general terms

• sarcoglycan

Component of

• sarcoglycan complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6443
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6443
• OMIM: https://mirror.omim.org/entry/600900
• OMIM: https://mirror.omim.org/entry/604286
• UniProt: http://www.uniprot.org/uniprot/Q16585.html