agrin (AGRN)

Function

• component of the basal lamina
• causes aggregation of acetylcholine receptors & acetylcholine-esterase on the surface of muscle fibers of the neuromuscular junction
• binds to laminin

Structure

• contains heparan sulfate chains as well as N-linked oligosaccharides & O-linked oligosaccharides (putative)
• contains 4 EGF-like domains
• contains 9 Kazal-like domains
• contains 2 laminin EGF-like domains
• contains 3 laminin G-like domains
• contains 1 NtA (N-terminal agrin) domain
• contains 1 SEA domain

Compartment

• secreted, extracellular space, extracellular matrix
• synaptic basal lamina at the neuromuscular junction

More general terms

• glycoprotein
• matrix protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=375790
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:375790
• OMIM: https://mirror.omim.org/entry/103320
• UniProt: http://www.uniprot.org/uniprot/O00468.html