biglycan; bone/cartilage proteoglycan I; PG-S1 (BGN, SLRR1A)

Function

• may be involved in collagen fiber assembly
• the two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate (putative)
• forms a ternary complex with MFAP2 & ELN

Structure

• homodimer
• belongs to the small leucine-rich proteoglycan (SLRP) family, class I subfamily
• contains 12 LRR repeats (leucine-rich repeats)

Compartment

• secreted, extracellular space, extracellular matrix (putative)

Expression

• found in several connective tissues, especially in articular cartilages

More general terms

• proteoglycan core protein
• matrix protein

Database

• UniProt: http://www.uniprot.org/uniprot/P21810.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=633
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:633
• OMIM: https://mirror.omim.org/entry/301870