basement membrane-specific heparan sulfate proteoglycan core protein; HSPG; perlecan; PLC (HSPG2)

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Function

Structure

Compartment

Expression

found in the basement membranes

Pathology

More general terms

References

  1. UniProt http://www.uniprot.org/uniprot/P98160.html
  2. Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org//genes/HSPG2ID40890ch1p36.html
  3. Wikipedia; Note: perlecan entry http://en.wikipedia.org/wiki/perlecan
  4. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=HSPG2
  5. Ruoslahti E, Yamaguchi Y. Proteoglycans as modulators of growth factor activities. Cell. 1991 Mar 8;64(5):867-9. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2001586
  6. Noonan DM, Fulle A, Valente P, Cai S, Horigan E, Sasaki M, Yamada Y, Hassell JR. The complete sequence of perlecan, a basement membrane heparan sulfate proteoglycan, reveals extensive similarity with laminin A chain, low density lipoprotein-receptor, and the neural cell adhesion molecule. J Biol Chem. 1991 Dec 5;266(34):22939-47. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1744087

Database