Fibroblast growth factor-binding protein 1 (FGF-binding protein 1, FGF-BP1, FGFBP-1, FGF-BP, 17 kD heparin-binding growth factor-binding protein, 17 kD HBGF-binding protein, HBp17, FGFBP1, FGFBP, HBP17)
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Function
- carrier protein
- release fibroblast-binding factors from extracellular matrix storage, thus enhances mitogenic activity of FGFs
- enhances FGF2 signaling during tissue repair, angiogenesis & in tumor growth
- component of a complex with FGFBP1, FGF1 & FGF2
- interacts with FGF1, FGF2, FGF7, FGF10, FGF22 & HSPG2
- keratinocyte mitogen
Compartment
secreted, peripheral membrane
Expression
- expressed in the suprabasal region of epidermis, in hair follicles, basement membrane at the dermo-epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin
- expressed in normal & wounded skin
- up-regulated in epithelial cells after skin injury
Pathology
- expression is significantly up-regulated in carcinogen- induced skin tumors, invasive squamous cell carcinomas, some colon cancer cell lines & tumors
- colocalizes with HSPG2 in pericellular environment of squamous cell carcinomas