fibroblast growth factor 1; FGF-1; acidic fibroblast growth factor; aFGF; endothelial cell growth factor; ECGF; heparin-binding growth factor 1; HBGF-1 (FGF1, FGFA)
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Function
- cell injury may liberate FGF-1
- FGF-1 forms homodimer via C30 disulfide in aerobic environment[5]
- homodimer weakly binds heparin & is inactive
- role in the regulation of cell survival, cell division, angiogenesis, cell differentiation & cell migration
- potent mitogen in vitro
- interacts with FGFR1, FGFR2, FGFR3 & FGFR4
- affinity between fibroblast growth factors (FGFs) & their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors
- found in a complex with FGFBP1, FGF1 & FGF2
- interacts with FGFBP1
- part of a Cu+2-dependent multiprotein aggregate containing FGF1, S100A13 & SYT1
- interacts with SYT1 (putative)
- interacts with S100A13
Structure
- monomer, homodimer
- belongs to the heparin-binding growth factors family
- precursor does not contain ER signal sequence
Compartment
- secreted
- within the cytoplasm, it is transported to the cell membrane & then secreted by a non- classical pathway that requires Cu+2 & S100A13
- secreted in a complex with SYT1 (putative)
Alternative splicing
named isoforms=2
Comparative biology
- injection of FGF-1 into the cerebral ventricles of mice or rats with type 2 diabetes conferred glucose control for at least 17 weeks
More general terms
References
- ↑ Machida CM et al NGF induction of the gene encoding the protease transin accompanies neuronal differentiation in PC12 cells. Neuron 1989 Jun;2(6):1587-96 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2560648
- ↑ Imamura T et al Recovery of mitogenic activity of a growth factor mutant with a nuclear translocation sequence. Science 249:1567 1990 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1699274
- ↑ OMIM https://mirror.omim.org/entry/131220
- ↑ Henderson B & Blake S Therapeutic potential of cytokine manipulation TIPS 13:145 1992 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1589908
- ↑ 5.0 5.1 T. Maciag, Holland Laboratory, American Red Cross, Rockville, MD
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2246
- ↑ UniProt http://www.uniprot.org/uniprot/P05230.html
- ↑ NIEHS-SNPs http://egp.gs.washington.edu/data/fgf1/
- ↑ Scarlett JM et al. Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents. Nat Med 2016 Jul; 22:800. PMID: https://www.ncbi.nlm.nih.gov/pubmed/27213816