fibroblast growth factor receptor 4; FGFR-4; CD334 (FGFR4, JTK2, TKF)
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Function
- receptor for acidic fibroblast growth factor
- does not bind to basic fibroblast growth factor
- binds FGF19
- interacts with KLB (putative)
- phosphorylated on Tyr
- phosphorylation requires presence of a functional (phosphorylated) FGFR1 & not necessarily by means of FGFR heterodimerization (putative)
Structure
- glycosylated (putative)
- belongs to the protein kinase superfamily, Tyr protein kinase family, fibroblast growth factor receptor subfamily
- contains 3 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 protein kinase domain
Compartment
Alternative splicing
named isoforms=2
Expression
- expressed in gastrointestinal epithelial cells, pancreas, & gastric & pancreatic cancer cell lines
- found in fetal adrenal gland
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P22455.html
- ↑ NIEHS SNPs http://egp.gs.washington.edu/data/fgfr4/
- ↑ Cross M, Dexter TM. Growth factors in development, transformation, and tumorigenesis. Cell. 1991 Jan 25;64(2):271-80. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1988148
- ↑ Partanen J et al FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern. EMBO J. 1991 Jun;10(6):1347-54. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1709094