fibroblast growth factor receptor 2; FGFR-2; keratinocyte growth factor receptor 2; CD332 (FGFR2, BEK, KGFR, KSAM)
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Function
- receptor for acidic & basic fibroblast growth factors
Structure
- belongs to the protein kinase superfamily, Tyr protein kinase family, fibroblast growth factor receptor subfamily
- contains 3 Ig-like C2-type domain (immunoglobulin-like) domains
- contains 1 protein kinase domain
Compartment
- cell membrane
- isoforms 14, 19: secreted
Alternative splicing
named isoforms=20
Expression
- found in adult mouse liver, lung, brain & kidney
Pathology
- defects in FGFR2 are a cause of:
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P21802.html
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=FGFR2
- ↑ Cross M, Dexter TM. Growth factors in development, transformation, and tumorigenesis. Cell. 1991 Jan 25;64(2):271-80. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1988148
- ↑ Partanen J et al Claesson-Welsh L, Alitalo K. FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern. EMBO J. 1991 Jun;10(6):1347-54. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1709094
Database
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2263
- OMIM: https://mirror.omim.org/entry/101200
- OMIM: https://mirror.omim.org/entry/101600
- OMIM: https://mirror.omim.org/entry/123150
- OMIM: https://mirror.omim.org/entry/123500
- OMIM: https://mirror.omim.org/entry/123790
- OMIM: https://mirror.omim.org/entry/149730
- OMIM: https://mirror.omim.org/entry/176943
- OMIM: https://mirror.omim.org/entry/207410
- OMIM: https://mirror.omim.org/entry/609579
- UniProt: http://www.uniprot.org/uniprot/P21802.html
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2263