fibroblast growth factor 10; FGF-10; keratinocyte growth factor 2 (FGF10)

Function

• role in the regulation of embryonic development, cell proliferation & cell differentiation
• required for normal branching morphogenesis
• may play a role in wound healing
• interacts with FGFR1 & FGFR2
• interacts with FGFBP1

Structure

• belongs to the heparin-binding growth factors family

Compartment

secreted (putative)

Pathology

• defects in FGF10 are the cause of autosomal dominant aplasia of lacrimal & salivary glands
• defects in FGF10 are a cause of Levy-Hollister syndrome

More general terms

• fibroblast growth factor
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2255
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2255
• OMIM: https://mirror.omim.org/entry/149730
• OMIM: https://mirror.omim.org/entry/180920
• OMIM: https://mirror.omim.org/entry/602115
• UniProt: http://www.uniprot.org/uniprot/O15520.html