fibroblast growth factor 7; FGF-7; heparin-binding growth factor 7; HBGF-7; keratinocyte growth factor (FGF7 KGF)

Function

• role in the regulation of embryonic development, cell proliferation & cell differentiation
• required for normal branching morphogenesis
• growth factor active on keratinocytes
• possible major paracrine effector of normal epithelial cell proliferation
• interacts with FGFBP1
• interacts with FGFR2
• affinity between fibroblast growth factors (FGFs) & their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors

Structure

• belongs to the heparin-binding growth factors family

Compartment

secreted

Expression

epithelial cell

More general terms

• fibroblast growth factor
• glycoprotein

More specific terms

• palifermin (Kepivance)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2252
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2252
• OMIM: https://mirror.omim.org/entry/148180
• UniProt: http://www.uniprot.org/uniprot/P21781.html