collagen 13 alpha-1 (COL13A1)

Function

• cell-matrix & cell-cell adhesion interactions required for normal development
• role in linkage between muscle fiber & basement membrane
• role in endochondral ossification of bone branching morphogenesis of lung
• binds heparin
• homotrimer, disulfide-linked
• nucleation of the collagen type 13 triple helix is likely to occur at the N-terminal region with triple helix formation proceeding from the N- to the C-terminus
• interacts with FN1, perlecan/HSPG2 & NID2

Compartment

cell membrane

Alternative splicing

named isoforms=9

Expression

• widely expressed
• expressed in both fetal & adult ocular tissues
• in the eye, expression is accentuated in the ciliary muscle, optic nerve & neural retina
• in early placenta, localized to fibroblastoid stromal cells of the placental villi, to endothelial cells of developing capillaries & to cells of the cytotrophoblastic columns, detected in large decidual cells of the decidual membrane & to stromal cells of the gestational endometrium, but not in epithelial cells in the endometrial glands

More general terms

• collagen subunit

Component of

• collagen type-13

Database

• OMIM: https://mirror.omim.org/entry/120350
• UniProt: http://www.uniprot.org/uniprot/Q5TAT6.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1305