Nidogen-2; NID-2; osteonidogen (NID2)

Function

• cell adhesion protein
• binds to collagen 1, collagen 4, perlecan & laminin 1
• does not bind fibulins
• role in cell-extracellular matrix interactions
• interacts with LAMA2

Structure

• highly N-glycosylated & O-glycosylated
• contains 5 EGF-like domains
  • contains 5 LDL-receptor class B repeats
  • contains 1 NIDO domain
  • contains 1 nidogen G2 beta-barrel domain
  • contains 2 thyroglobulin type-1 domains

Compartment

• secreted, extracellular matrix
• widely distributed in basement membranes

Expression

• expressed in heart, placenta, bone > pancreas, kidney, skeletal muscle

More general terms

• glycoprotein
• cell adhesion protein
• Ca+2 binding protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=22795
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:22795
• OMIM: https://mirror.omim.org/entry/605399
• UniProt: http://www.uniprot.org/uniprot/Q14112.html