nidogen-1; NID-1; entactin (NID1, NID)

Function

• sulfated glycoprotein widely distributed in basement membranes & tightly associated with laminin
• also binds to collagen 4 & perlecan
• probably has a role in cell-extracellular matrix interactions
• interacts with FBLN1 & LGALS3BP (putative)
• interacts with PLXDC1

Structure

• N-glycosylated & O-glycosylated
• contains 6 EGF-like domains
• contains 4 LDL-receptor class B repeats
• contains 1 NIDO domain
• contains 1 nidogen G2 beta-barrel domain
• contains 1 thyroglobulin type-1 domain

Compartment

• secreted, extracellular space, extracellular matrix, basement membrane

Alternative splicing

named isoforms=2

More general terms

• glycoprotein
• matrix protein

Additional terms

• Nidogen-2; NID-2; osteonidogen (NID2)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4811
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4811
• OMIM: https://mirror.omim.org/entry/131390
• UniProt: http://www.uniprot.org/uniprot/P14543.html