plexin domain-containing protein 1 (tumor endothelial marker 7, tumor endothelial marker 3, PLXDC1, TEM3, TEM7)

Function

• may interact with cortactin

Structure

• N-glycosylated
• belongs to the plexin family

Compartment

• isoform 1: membrane
• isoforms 2 & 3: secreted
• isoform 4: cytoplasm

Alternative splicing

named isoforms=4

Expression

• not detectable in endothelial cells from normal tissue
• detected in endothelial cells from colorectal cancer, & in endothelial cells from primary cancers of the lung, liver, pancreas, breast & brain

More general terms

• glycoprotein
• secreted protein
• membrane protein
• tumor endothelial marker

Database

• OMIM: https://mirror.omim.org/entry/606826
• UniProt: http://www.uniprot.org/uniprot/Q8IUK5.html