heparin-binding EGF-like growth factor; heparin-binding protein; HB-EGF; HBEGF; diphtheria toxin receptor; DT-R (HBEGF, DTR, DTS, HEGFL)

Function

• may be involved in macrophage-mediated cellular proliferation
• mitogenic for fibroblasts & smooth muscle but not endothelial cells
• it is able to bind EGF receptors with higher affinity than EGF itself & is a far more potent mitogenfor smooth muscle cells than EGF
• inducer of increased vascular permeability
• acts as a diphtheria toxin receptor

Structure

contains 1 EGF-like domain

Compartment

• heparin-binding EGF-like growth factor:
  • secreted, extracellular space
  • mature HB-EGF is released into the extracellular space & probably binds to a receptor
• proheparin-binding EGF-like growth factor:
  • cell membrane; single-pass type 1 membrane protein

Laboratory

• heparin-binding protein in CSF is a marker for bacterial meningitis Expession:
• released from activated neutrophils in severe sepsis

More general terms

• glycoprotein
• secreted peptide
• growth factor
• membrane protein

Additional terms

• heparin-binding protein in CSF

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1839
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1839
• OMIM: https://mirror.omim.org/entry/126150
• UniProt: http://www.uniprot.org/uniprot/Q99075.html