chromosomal translocation t(8;11) (gamma-heregulin)
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Introduction
- chromosomal translocation t(8;22) involving NRG1 with ODZ4 produces gamma-heregulin, a soluble activating ligand for the ERBB2 receptor-ERBB3 receptor complex that acts as an autocrine growth factor in a specific breast cancer cell line (MDA-MB-175)
- gamma-heregulin is not detected in breast carcinoma samples