neuregulin-4; NRG-4 (NRG4)

Function

• low affinity ligand for the ERBB4 tyrosine kinase receptor
• concomitantly recruits ERBB1 coreceptor& ERBB2 coreceptor, resulting in ligand-stimulated Tyr phosphorylation & activation of the ERBB receptors
• does not bind to the ERBB1 receptor, ERBB2 receptor & ERBB3 receptor (putative)
• proteolytic cleavage close to the plasma membrane on the external face leads to the release of soluble growth factor form (putative)
• extensive glycosylation precedes the proteolytic cleavage
• interacts with ERBB4 (putative)

Structure

• the cytoplasmic domain may be involved in the regulation of trafficking & proteolytic processing
• regulation of proteolytic processing involves initial intracellular domain dimerization (putative)
• ERBB receptor binding is elicited entirely by the EGF-like domain (putative)
• belongs to the neuregulin family
• contains 1 EGF-like domain

Compartment

• pro-neuregulin-4
  • plasma membrane
  • single-pass type 1 membrane protein
  • does not seem to be active (putative)
• neuregulin-4: secreted (putative)

More general terms

• neuregulin
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=145957
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:145957
• OMIM: https://mirror.omim.org/entry/610894
• UniProt: http://www.uniprot.org/uniprot/Q8WWG1.html