proliferation-associated protein 2G4; cell cycle protein p38-2G4 homolog; hG4-1; ErbB3-binding protein 1 (PA2G4, EBP1)
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Function
- may play a role in a ERBB3-regulated signal transduction
- seems be involved in growth regulation
- corepressor of the androgen receptor (AR)
- regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG)
- inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity
- binds RNA
- associates with 28S, 18S & 5.8S mature rRNAs, several rRNA precursors & probably U3 small nucleolar RNA
- may be involved in regulation of intermediate & late steps of rRNA processing
- may be involved in ribosome assembly
- phosphorylated on Ser & Thr
- phosphorylation is enhanced by HRG treatment
- basal phosphorylation is PKC-dependent
- HRG-induced phosphorylation is predominantly PKC-independent
- interacts with the cytoplasmic domain of non-phosphorylated ERBB3; the interaction requires PKC activity
- interacts with AR
- treatment with HRG leads to dissociation from ERBB3 & increases association with AR
- interacts with NCL/nucleolin
- component of a ribonucleoprotein complex containing at least PA2G4, NCL, TOP1, PABPC2, RPLP0, acetylated histone H1 (HIST1H1A or H1F1), histone H1 2/4, RPL4, RPL8, RPL15, RPL18, RPL18A, RPL21, RPL11, RPL12, RPL28, RPL27, RPLP2 & RPL24
- interacts with HDAC2
- interacts with RB1
- the interaction is enhanced upon PA2G4 dephosphorylation
Structure
belongs to the peptidase M24 family
Compartment
Expression
- expressed in several cell lines tested, including primary & transformed cell lines
Pathology
- mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (putative)
Notes
- does not contain metal cofactor
- does not have aminopeptidase activity