polyadenylate-binding protein 1; poly(A)-binding protein 1; PABP 1 (PABPC1, PAB1, PABP1, PABPC2)

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Function

binds the poly(A) tail of mRNA
may be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing
its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2
can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo
may be involved in translationally coupled mRNA turnover
implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational & decay interplay of FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain
methylated by CARM1
component of an autoregulatory ribonucleoprotein complex
interacts with IGF2BP1
part of a complex associated with the FOS mCRD domain, consisting of HNRPD, SYNCRIP, PAIP1 & CSDE1/UNR
interacts with the PABPC1-interacting motif-1 (PAM1) & -2 (PAM2) of PAIP1 & PAIP2
interacts with PAIP1 with a 1:1 stoichiometry & with PAIP2 with a 1:2 stoichiometry
interaction with CSDE1 is direct & RNA-independent
found in a mRNP complex with YBX2
interacts with PAPD4/GLD2
identified in the spliceosome C complex
interacts with PIWIL1 (putative)
interacts with NFX1

Arg-493 is dimethylated, probably to asymmetric dimethylarginine
the RNA-binding domains RRM1 & RRM2 & the C-terminus (last 138 amino acids) regions interact with the PABPC1-interacting motif-1 (PAM1) & -2 (PAM2) of PAIP1, respectively
the RNA-binding domains RRM2 & RRM3 & the C-terminus (last 138 amino acids) regions interact with the PABPC1- interacting motif-1 (PAM1) & -2 (PAM2) of PAIP2, respectively
belongs to the polyadenylate-binding protein type-1 family
contains 1 PABC domain
contains 4 RRM domain (RNA recognition motif)s