polyadenylate-binding protein-interacting protein 2 (poly(A)-binding protein-interacting protein 2, PABP-interacting protein 2, PAIP-2, PAIP2)

Function

• repressor in the regulation of translation initiation of poly[A]-containing mRNAs
• inhibitory activity on translation is mediated via action on PABPC1
• displaces interaction of PABPC1 with poly[A]-RNA
  • via PABPC1-interacting motif-1 (PAM1)
• competes with PAIP1 for binding to PABPC1
• association with PABPC1 results in disruption of cytoplasmic poly[A] RNP structure organization
• interacts with 2nd & 3rd RRM domains & C-terminus regions of PABPC1 in a 2:1 stoichiometry

Compartment

cytoplasm

More general terms

• polyadenylate binding protein interacting protein

Additional terms

• polyadenylate binding protein
• polyadenylate-binding protein-interacting protein 1 (poly[A]-binding protein-interacting protein 1, PABP-interacting protein 1, PAIP-1, PAIP1)

Database

• OMIM: https://mirror.omim.org/entry/605604
• UniProt: http://www.uniprot.org/uniprot/Q9BPZ3.html