poly(A) RNA polymerase GLD2 (hGLD-2, PAP-associated domain-containing protein 4, PAPD4, GLD2)

Function

• cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail
• in contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs
• interacts with CPEB1, CPEB2, CPSF1 & PABPC1 ATP + RNA(n) = diphosphate + RNA(n+1)

Structure

• belongs to the DNA polymerase type-B-like family, GLD2 subfamily

Compartment

cytoplasm (putative). nucleus

Alternative splicing

named isoforms=2

Expression

• expressed in brain
• within brain, expressed in cerebellum, hippocampus & medulla

More general terms

• enzyme

Database

• UniProt: http://www.uniprot.org/uniprot/Q6PIY7.html