cleavage & polyadenylation specificity factor subunit 1; cleavage & polyadenylation specificity factor 160 kD subunit; CPSF 160 kD subunit (CPSF1, CPSF160)

Function

• component of the CPSF complex involded in pre-mRNA 3'-end formation
• this subunit is involved in the RNA recognition step of the polyadenylation reaction
• found in a complex with CPSF1, FIP1L1 & PAPOLA
• interacts with FIP1L1, PAPD4/GLD2 & SRRM1

Structure

• belongs to the CPSF1 family
• the N-terminus is blocked

Compartment

nucleus, nucleoplasm

More general terms

• protein subunit
• nuclear protein
• RNA-binding protein
• phosphoprotein

Component of

• cleavage & polyadenylation specificity factor (CPSF) complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=29894
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:29894
• OMIM: https://mirror.omim.org/entry/606027
• UniProt: http://www.uniprot.org/uniprot/Q10570.html