pre-mRNA 3'-end-processing factor FIP1 (FIP1-like 1, factor interacting with PAP, hFip1, rearranged in hypereosinophilia, FIP1L1, FIP1, RHE)

Function

• component of CPSF complex
• FIP1L1 contributes to poly(A) site recognition
• stimulates poly(A) addition
• binds to U-richRNA sequence elements surrounding poly(A) site
• tethers poly(A) polymerase to the CPSF complex (putative)

Compartment

nucleus

Alternative splicing

named isoforms=4

Pathology

• fusion of FIP1L1 & PDGFRA (FIP1L1-PDGFRA), due to an interstitial chromosomal deletion del(4)(q12q12), is the cause of some cases of hypereosinophilic syndrome

More general terms

• nuclear protein

Database

• OMIM: https://mirror.omim.org/entry/607685
• OMIM: https://mirror.omim.org/entry/607686
• UniProt: http://www.uniprot.org/uniprot/Q6UN15.html