CD140a; PDGF-R-alpha; alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140a antigen (PDGFRA)

Function

• cell surface receptor
• binds both PDGFA & PDGFB
• has tyrosine-protein kinase activity
• homodimer, & heterodimer with PDGFRB
• interacts with SH2 domain of SHB via phosphorylated Tyr-720 (putative)
• interacts with SH2 domain of SHF via phosphorylated Tyr-720

Structure

• belongs to the protein kinase superfamily, Tyr protein kinase family, CSF-1/PDGF receptor subfamily
• contains 5 Ig-like C2-type domain (immunoglobulin-like) domains
• contains 1 protein kinase domain

Compartment

membrane

Alternative splicing

named isoforms=2

Pathology

• fusion of PDGFRA & FIP1L1 (FIP1L1-PDGFRA), due to an interstitial chromosomal deletion, is the cause of some cases of hypereosinophilic syndrome

Pharmacology

• olaratumab (Lartruvo), a PDGFRA inhibitor, used in combination with doxorubicin for treatment of advanced soft tissue sarcomas

More general terms

• platelet-derived growth factor [PDGF] receptor
• oligomerizing protein
• CD antigen

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5156
• OMIM: https://mirror.omim.org/entry/173490
• OMIM: https://mirror.omim.org/entry/607685
• UniProt: http://www.uniprot.org/uniprot/P16234.html