SH2 domain-containing adapter protein F (SHF)

Function

• adapter protein which may play a role in the regulation of apoptosis in response to PDGF
• interacts with phosphorylated Tyr-720 of PDGFRA via its SH2 domain
• may become phosphorylated upon binding to PDGFRA

Structure

contains 1 SH2 domain

Alternative splicing

named isoforms=2

Expression

• expressed in skeletal muscle, brain, liver, prostate, testis, ovary, small intestine & colon

More general terms

• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q7M4L6.html