SH2 domain-containing adapter protein B (SHB, Shb adaptor protein)

Function

• adapter protein
• regulates several signal transduction cascades by linking activated receptors to downstream signaling components
• role in angiogenesis by regulating FGFR1, VEGFR2 & PDGFR signaling (putative)
• role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis & neuronal cells differentiation by mediating basic-FGF & NGF-induced signaling cascades (putative)
• role in IRS1 & IRS2 signaling in insulin-producing cells (putative)
• interacts with PTPN11
• interacts with ligand-activated receptors: PDGFRA, PDGFRB, FGFR1, KDR/VEGFR2, IL2RB & IL2RG
• interacts with EPS8 & V-SRC
• interacts with GRB2 & GRAP
• interacts with CD3Z
• interacts with tyrosine-phosphorylated LAT upon T-cell antigen receptor activation
• interacts with PLCG1, ZAP70, LCP2/SLP-76, VAV1, GRAP2 JAK1 & JAK3, PTK2/FAK1, CRK/CrKII, IRS2
• SH2 domain preferentially binds phosphopeptides with consensus sequence Y-[TVI]-X-L & mediates interaction with PDGFRA, PDGFRB, FGRFR1, IL2RB, IL2RG, CD3Z & CRK/CrKII
• phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGRF1 or VEGFR2 activation

Structure

• contains 1 SH2 domain

Compartment

• cytoplasm
• associates with membrane lipid rafts upon TCR stimulation

Alternative splicing

named isoforms=2

Expression

widely expressed

More general terms

• phosphoprotein
• proto oncogene protein

Database

• OMIM: https://mirror.omim.org/entry/600314
• UniProt: http://www.uniprot.org/uniprot/Q15464.html