epidermal growth factor receptor kinase substrate 8 (EPS8)

Function

• upon binding to EGF receptor, enhances EGF-dependent mitogenic signals
• can bind multiple cellular targets
• phosphorylated by several receptor tyrosine kinases
• homodimer (putative)
• interacts with LANCL1
• interacts with BAIAP2
• interacts with SHB

Structure

• the SH3 domain mediates interaction with SHB
• belongs to the EPS8 family
• contains 1 PH domain
• contains 1 SH3 domain

Expression

• expressed in all tissues analyzed, including heart, brain, placenta, lung, liver, skeletal muscle, kidney & pancreas
• expressed in all epithelial & fibroblastic lines analyzed
• expressed in some, but not all, hematopoietic cells

More general terms

• phosphoprotein

Component of

• ABI1/EPS8/SOS1 complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2059
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2059
• OMIM: https://mirror.omim.org/entry/600206
• UniProt: http://www.uniprot.org/uniprot/Q12929.html