LanC-like protein 1; 40 kD erythrocyte membrane protein; p40 (LANCL1, GPR69A)

Function

• may play a role in EPS8 signaling
• binds glutathione
• interacts with the C-terminal of STOM
• interacts with the EPS8 SH3 domain
• interaction with EPS8 is inhibited by glutathione binding

Structure

• the N-terminus is blocked
• belongs to the LanC-like protein family

Compartment

• cytoplasm
• membrane, peripheral membrane
• nucleus

Expression

• ubiquitous
• strongly expressed in brain, spinal cord, pituitary gland, kidney, heart, skeletal muscle, pancreas, ovary & testis
• detected in erythrocytes, brain, kidney, testis, ovary, heart, lung, placenta & spleen (at protein level)

Pathology

• detected at the surface of Maurer's clefts in malaria- infected erythrocytes at late stages of parasite development
• interacts with P falciparum SBP1

Notes

• originally thought to be a G-protein coupled receptor

More general terms

• LanC-like protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10314
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10314
• OMIM: https://mirror.omim.org/entry/604155
• UniProt: http://www.uniprot.org/uniprot/O43813.html