erythrocyte band 7 integral membrane protein; stomatin; protein 7.2b (STOM BND7 EPB72)

Introduction

Band # from SDS gel of erythrocyte ghosts.

Function

-thought to regulate cation conductance

• may regulate ACCN1 & ACCN3 gating (putative)
• interacts with ACCN1, ACCN2 & ACCN3 (putative)
• interacts with LANCL1

Structure

• homooligomer containing between 9 & 12 monomers
• belongs to the band 7/mec-2 family

Compartment

• cell membrane, cytoplasmic side
• lipid-anchor, cytoplasmic side
• melanosome
• exposed on the cytoplasmic surface of the membrane
• associated with lipid rafts
• concentrates preferentially in plasma membrane protrusions & in a juxta-nuclear region which may represent Golgi-derived vesicles
• colocalizes with actin

Expression

widely expressed

Pathology

• stomatin is deficient in hereditary stomatocytosis

More general terms

• plasma membrane protein
• phosphoprotein

Additional terms

• lipid rafts; detergent-insoluble glycolipid-rich domains (DIGs); glycolipid-enriched membranes (GEMs); low-density Triton-insoluble (LDTI) complexes

Database

• UniProt: http://www.uniprot.org/uniprot/P27105.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2040
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2040
• OMIM: https://mirror.omim.org/entry/133090