amiloride-sensitive cation channel 3 (acid-sensing ion channel 3, ASIC3, hASIC3, testis sodium channel 1, hTNaC1, ACCN3, ASIC3, SLNAC1, TNAC1)
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Function
- cation channel with high affinity for Na+
- gated by extracellular H+
- inhibited by amiloride
- generates a biphasic current
- fast inactivating & slow sustained phase
- in sensory neurons, mediates pain induced by acidosis from ischemia or inflammation (putative)
- involved in hyperalgesia (putative)
- role in mechanoreception (putative)
- phosphorylated by PKA, PKC
- potentiated by FMRFamide-related neuropeptides
- sensitized & potentiated by NPSF
- regulated by lactate & Ca+2
- inhibited by anti-inflammatory drugs, like salicylic acid
- sensitized & potentiated by NPFF
- interacts with STOM & DLG4
- interacts with LIN7B, MAGI1/BAIAP1, GOPC, ACCN1
- heteromeric channel assembly seems to modulate channel properties
Structure
- the PDZ domain-binding motif is involved in interaction with LIN7A, GOPC & MAGI1
- belongs to the amiloride-sensitive Na+ channel family
Compartment
- cell membrane, cytoplasm
- cell surface expression stabilized by interaction with LIN7B
- cytoplasmic retention stabilized by interaction with DLG4
Alternative splicing
named isoforms=4
Expression
- expressed by sensory neurons
- strongly expressed in brain, spinal cord, lung, lymph nodes, kidney, pituitary, heart, testis
- expressed in fetal tissues
- expression increases in lung & kidney adult tissues
Notes
- potentiated by FMRFamide-related neuropeptides sensitized & potentiated by NPSF
- regulated by lactate & Ca+2
- inhibited by anti-inflammatory drugs, including salicylic acid (putative)
- sensitized & potentiated by NPFF