amiloride-sensitive Na+ channel or lung Na+ channel

Function

• non voltage-gated Na+ channel
• mediates electrodiffusion of sodium through apical membrane of epithelial cells
• controls resporption of sodium in kidney lung, sweat glands
• role in taste perception

Inhibition:

• inhibited by amiloride

Structure

• heterotetramer consisting of two alpha, one beta & one gamma subunit
• alternative form with delta, replacing an alpha subunit

Compartment

• apical cell membrane

More general terms

• Na+ channel
• plasma membrane protein
• multisubunit protein

Database

• OMIM: https://mirror.omim.org/entry/601328