WW domain-containing protein 3; membrane-associated guanylate kinase, WW & PDZ domain-containing protein 1; BAI1-associated protein 1; BAP-1; membrane-associated guanylate kinase inverted 1; MAGI-1; atrophin-1-interacting protein 3; AIP-3; WWP3; trinucleotide repeat-containing gene 19 protein (MAGI1, AIP3, BAIAP1, BAP1, TNRC19)

Function

• may play a role as scaffolding protein at cell-cell junctions
• may regulate acid-induced ACCN3 currents
• interacts with:
  • SYNPO, DRPLA via WW domain
  • ACTN4 via PDZ domain 5
  • NET1 via PDZ domain 1
  • BAI1, ESAM, LRP2, CXADR, ACCN3, AMOT
• isoform 2 interacts with CTNNB1

Structure

• contains 1 guanylate kinase-like domain
• contains 6 PDZ domain (DHR domain)s
• contains 2 WW domains

Compartment

• membrane-associated-associated
• localizes to epithelial cells tight junctions

Alternative splicing

• named isoforms=7
• additional isoforms seem to exist

Expression

• widely expressed
• not expressed in skeletel muscle
• isoform 1, isoform 2 & isoform 6 are highly expressed in colon, kidney, lung, liver, & pancreas
• isoform 5 is predominantly expressed in brain & heart
• isoform 3 & isoform 4 are highly expressed in pancreas & brain

More general terms

• scaffold protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9223
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9223
• OMIM: https://mirror.omim.org/entry/602625
• UniProt: http://www.uniprot.org/uniprot/Q96QZ7.html