synaptopodin (SYNPO, KIAA1029)

Function

• actin-associated protein
• modulating actin-based shape & motility of
  • dendritic spines
  • renal podocyte foot processes
• formation of spine apparatuses in spines of neurons
• synaptic plasticity
• isoform 2 is phosphorylated on Ser-826, Thr-836, Ser-840 & Ser-871
• interacts with BAIAP1, actin
• interacts (via PPxY motifs) with WWC1 (via WW domains)

Structure

• O-glycosylated (putative)
• belongs to the synaptopodin family

Compartment

• cytoplasm
• localized to tight junctions
• in brain, localized to postsynaptic densities & perikarya
• associated with dendritic spines of a subset of synapses

Alternative splicing

named isoforms=3

Expression

expressed in cerebral cortex

More general terms

• cytoskeletal protein
• phosphoprotein
• glycoprotein

Additional terms

• synaptopodin-2 (myopodin, genethonin 2, SYNPO2)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11346
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11346
• OMIM: https://mirror.omim.org/entry/608155
• UniProt: http://www.uniprot.org/uniprot/Q8N3V7.html