synaptopodin-2 (myopodin, genethonin 2, SYNPO2)

Function

• actin-binding & actin-bundling activity
• nuclear export is XPO1-dependent

Structure

• belongs to the synaptopodin family
• contains 1 PDZ domain (DHR domain)

Compartment

• nucleus, cytoplasm
• shuttles between nucleus & cytoplasm (differentiation- dependent, stress-induced)
• localizes to Z-disk in mature striated muscle

More general terms

• cytoskeletal protein

Additional terms

• synaptopodin (SYNPO, KIAA1029)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9UMS6.html