brain-specific angiogenesis inhibitor 1

Function

• phosphatidylserine receptor
• enhances engulfment of apoptotic cells
• likely to be a potent inhibitor of angiogenesis in brain
• may play a role as a mediator of the p53 signal in suppression of glioblastoma
• may function in cell adhesion & signal transduction in the brain
• interacts with ELMO1 & DOCK1
• when bound to ELMO1 & DOCK1, it may act as a module to promote engulfment
• interacts with MAGI1, MAGI3, BAIAP2 & PHYHIP

Structure

• the TSP1 repeats inhibit in vivo angiogenesis in rat cornea induced by BFGF
• belongs to the G-protein coupled receptor 2 family LN-TM7 subfamily
• contains 1 GPS domain
• contains 5 TSP type-1 domains

Compartment

• cell membrane; multi-pass membrane protein
• likely to be concentrated at cell-cell adhesion sites

Expression

• specifically expressed in brain
• no expression (or very low expression) in some glioblastoma cell lines & cancer tissues
• no expression in astrocytes
• expression induced by p53

More general terms

• brain-specific angiogenesis inhibitor

Additional terms

• angiogenesis (neovascularization, NV)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=575
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:575
• OMIM: https://mirror.omim.org/entry/602682
• UniProt: http://www.uniprot.org/uniprot/O14514.html