dedicator of cytokinesis protein 1; 180 kD protein downstream of CRK; DOCK180 (DOCK1)

Function

• cytoskeletal rearrangements for phagocytosis of apoptotic cells & cell motility
• guanine nucleotide exchange factor (GEF)
  • activates Rac Rho small GTPases by exchanging bound GDP for free GTP
  • GEF activity may be enhanced by ELMO1
• interacts with the SH3 domains of CRK & NCK2
• interacts with nucleotide-free RAC1 via its DHR-2 domain
• interacts with ELMO1, ELMO2, ELMO3 via its SH3 domain
• interacts with RAC1 & BAI1

Structure

• the DHR-2 domain is necessary & sufficient for GEF activity
• belongs to the DOCK family
• contains 1 DHR-1 domain
• contains 1 DHR-2 domain
• contains 1 SH3 domain

Compartment

• cytoplasm
• recruited to membranes via its interaction with PIP3 (phosphatidylinositol 3,4,5-triphosphate)

Expression

• expressed in placenta, lung, kidney, pancreas, ovary > thymus, testes, colon

More general terms

• dedicator of cytokinesis protein (DOCK)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1793
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1793
• OMIM: https://mirror.omim.org/entry/601403
• UniProt: http://www.uniprot.org/uniprot/Q14185.html