engulfment & cell motility protein 3 (ELMO3)

Function

• role in cytoskeletal rearrangements required for phagocytosis of apoptotic cells & cell motility
• acts in association with DOCK1 & CRK
• interacts directly with the SH3-domain of DOCK1 via its SH3-binding site
• component of a complex with DOCK1 & RAC1
• may enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1

Structure

• contains 1 ELMO domain
• contains 1 PH domain

Compartment

cytoplasm

More general terms

• engulfment & cell motility protein (ELMO)

Database

• OMIM: https://mirror.omim.org/entry/606422
• UniProt: http://www.uniprot.org/uniprot/Q96BJ8.html