engulfment & cell motility protein 1 (CED-12 homolog, ELMO1, KIAA0281)

Function

• involved in cytoskeletal rearrangements required phagocytosis of apoptotic cells & cell motility
• interacts with DOCK1 & CRK
  • part of a complex with DOCK1 & CRK
• interacts directly with the SH3-domain of DOCK1 via its SH3-binding site
• may enhance the guanine nucleotide exchange factor (GEF) activity of DOCK
• part of a complex with DOCK1 & RAC1
• phosphorylated by HCK

Structure

• contains 1 ELMO domain
• contains 1 PH domain

Compartment

• cytoplasm, cell membrane
• translocation to plasma membrane seems to be mediated by DOCK1 & CRK

Alternative splicing

named isoforms=2

Expression

• widely expressed, higher expression in spleen, placenta

More general terms

• phosphoprotein
• engulfment & cell motility protein (ELMO)

Database

• OMIM: https://mirror.omim.org/entry/606420
• UniProt: http://www.uniprot.org/uniprot/Q92556.html