hck protein; tyrosine-protein kinase HCK; p59-HCK/p60-HCK; hemopoietic cell kinase (HCK)

Function

• may serve role in signaling pathway coupling the Fc receptor to activation of the respiratory burst
• may have role in neutrophil migration & may regulate the degranulation process of neutrophils
• may bind to HIV-1 Nef & VIF through its SH3 domain; interaction would stimulate its tyrosine-kinase activity

Structure

• SH3 domain mediates binding to HIV-1 Nef
• belongs to the Tyr protein kinase family, SRC subfamily
• contains 1 protein kinase domain
• contains 1 SH2 domain
• contains 1 SH3 domain
• isoform p59-HCK contains a N-myristoyl glycine at position 3
• contains a S-palmitoyl cysteine at position 4 (putative)

Compartment

• isoform p59-HCK: membrane, lipid-anchor
• isoform p60-HCK: membrane, lipid-anchor, cytoplasm

Alternative initiation

• named isoforms=2

Expression

• expressed predominantly in cells of the myeloid & B-lymphoid lineages

More general terms

• src proto-oncogene protein family

Database

• OMIM: https://mirror.omim.org/entry/142370
• UniProt: http://www.uniprot.org/uniprot/P08631.html