Golgi reassembly-stacking protein 2; GRS2; Golgi phosphoprotein 6; GOLPH6; Golgi reassembly-stacking protein of 55 kDa; GRASP55; p59 (GORASP2, GOLPH6)

Function

• role in the assembly & membrane stacking of Golgi cisternae, & in the process by which Golgi stacks reform after mitotic breakdown
• may regulate intracellular transport & presentation of a defined set of transmembrane proteins, such as transmembrane TGFA
• myristoylated & palmitoylated
• myristoylation is essential for the Golgi targeting (putative)
• phosphorylated in mitotic cells
• forms a RAB2 effector complex with BLZF1/Golgin 45 in the medial Golgi
• interacts with members of the p24 cargo receptors
• interacts with CNIH & the cytoplasmic domain of transmembrane TGFA, prior its transit in the trans-Golgi
• does not interact with GM130
• interacts with KCTD5
• interacts with TMED2 & TMED3

Structure

• belongs to the GORASP family
• contains 1 PDZ domain (DHR domain)

Compartment

• Golgi membrane; lipid-anchor

Alternative splicing

named isoforms=2

More general terms

• Golgi reassembly stacking protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26003
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26003
• OMIM: https://mirror.omim.org/entry/608693
• UniProt: http://www.uniprot.org/uniprot/Q9H8Y8.html