cornichon homolog 1; CNIH-1; cornichon family AMPA receptor auxiliary protein 1; protein cornichon homolog; T-cell growth-associated molecule 77; TGAM77 (CNIH1 CNIH CNIL UNQ155/PRO181)

Function

• role in selective transport & maturation of TGF-alpha family proteins
• interacts with AREG immature precursor & with immature TGFA, i.e. with a prosegment & lacking full N-glycosylation, but not with the fully N-glycosylated form
• in the Golgi, may form a complex with GORASP55 & transmembrane TGFA

Structure

belongs to the cornichon family

Compartment

membrane

Expression

• expressed in heart, liver, skeletal muscle, pancreas, adrenal medulla & cortex, thyroid, testis, spleen, appendix, peripheral blood lymphocytes, bone marrow > brain, placenta, lung, kidney, ovary, small intestine, stomach, lymph node, thymus, fetal liver

Pathology

• expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study)

More general terms

• cornichon family protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10175
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10175
• OMIM: https://mirror.omim.org/entry/611287
• UniProt: http://www.uniprot.org/uniprot/O95406.html