Golgin 45 (basic leucine zipper nuclear factor 1, JEM-1, p45 basic leucine-zipper nuclear factor, BLZF1, JEM1)

Function

• Golgi structure
• protein transport from endoplasmic reticulum (ER) through Golgi to the cell surface
• interacts with GRASP55 and with GTP-bound form of RAB2, but not with other Golgi Rab proteins
• GRASP55 & BLZF1 form a RAB2 effector complex on medial Golgi

Compartment

• Golgi lumen
• isoform 1: nucleus
• isoform 2: cytoplasm

Alternative splicing

named isoforms=2

Expression

• ubiquitous
• up-regulated by retinoids

Pathology

• found in cell lines derived from several hematopoietic pathologies: T-cell leukemia, pro-B cell, pre-B cell, myeloma, & plasmacytoma cell lines, but not in Burkitt lymphoma cells

More general terms

• golgin (GOLGI autoantigen)
• basic leucine zipper (bZIP) family protein

Database

• OMIM: https://mirror.omim.org/entry/608692
• UniProt: http://www.uniprot.org/uniprot/Q9H2G9.html