cytoplasmic protein NCK2; NCK adaptor protein 2; Nck-2; SH2/SH3 adaptor protein NCK-beta (NCK2)

Function

• adapter protein which associates with Tyr-phosphorylated growth factor receptors or their cellular substrates
• maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1
• interacts with DOCK1, PINCH & TGFB1I1
• part of a complex containing PPP1R15B, PP1 & NCK2

Structure

• contains 1 SH2 domain
• contains 3 SH3 domains

Compartment

• cytoplasm, endoplasmic reticulum

Expression

ubiquitous

More general terms

• nck adaptor protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8440
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8440
• OMIM: https://mirror.omim.org/entry/604930
• UniProt: http://www.uniprot.org/uniprot/O43639.html