LIM & senescent cell antigen-like-containing domain protein 1 (particularly interesting new Cys-His protein 1, PINCH-1, NY-REN-48 antigen, LIMS1, PINCH, PINCH1)

Function

• effector of integrin & growth factor signaling
• couples surface receptors to downstream signaling molecules
• regulation of cell survival, cell proliferation, cell differentiation
• focal adhesion protein
• component of complex ILK-PINCH
• interacts ILK, NCK2

Compartment

cell junction, focal adhesion, cytoplasmic side

Expression

expressed in most tissues, except in the brain

More general terms

• LIM & senescent cell antigen-like-containing domain protein

Component of

• ILK-PINCH complex

Database

• OMIM: https://mirror.omim.org/entry/602567
• UniProt: http://www.uniprot.org/uniprot/P48059.html