integrin-linked protein kinase; 59 kD serine/threonine protein kinase; ILK-1; ILK-2; p59ILK (ILK, ILK1, ILK2)

^[1]^[2]

Function

receptor-proximal protein kinase regulating integrin- mediated signal transduction
may act as a mediator of inside-out integrin signaling
focal adhesion protein part of the complex ILK-PINCH
- this complex is considered to be one of the convergence points of integrin- & growth factor-signaling pathway
possible role in mediating cell architecture, adhesion to integrin substrates & anchorage-dependent growth in epithelial cells
phosphorylates beta-1 & beta-3 integrin subunit on Ser & Thr,
phosphorylates AKT1 & GSK3B
stimulated rapidly but transiently by both cell fibronectin interactions, as well as by insulin (PI3-K-dependent), likely via the binding of Ptdins(3,4,5)P3 with a PH-like domain of ILK
autophosphorylated on Ser
interacts with cytoplasmic domain of integrin beta-1
interacts with & is activated by LIMD2
may also interact with integrin beta-2, integrin beta-3 &/or integrin beta-5
interacts (via ANK repeats) with LIMS1 & LIMS2
interacts with parvins & probably TGFB1I1
interacts (via ANK repeats) with EPHA1 (via SAM domain);
- stimulated by EFNA1 but independent of the kinase activity of EPHA1

expressed in heart > skeletal muscle, pancreas & kidney > placenta, lung & liver

↑ UniProt http://www.uniprot.org/uniprot/Q13418.html
↑ ^2.0 ^2.1 Peng H et al LIMD2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase. Cancer Res March 1, 2014 74; 1390 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24590809 <Internet> http://cancerres.aacrjournals.org/content/74/5/1390.abstract