CD61 (integrin-beta 3, platelet membrane glycoprotein IIIA, GPIIIA, ITGB3, GP3A)
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Function
- associates with integrin alpha-2b (CD41) in integrin alpha-2b/beta-3
Expression
Pathology
- defects associated with Glanzmann thrombasthenia
- expressed in AML M7, some cases of AML M6
Laboratory
- HPA-1 type in blood
- HPA-4 type in blood
- HPA-6 type in blood Comparative Biology:
- in vitro & in mice, integrin alpha-V/beta-3 is a marker of breast carcinoma, lung carcinoma, & pancreatic carcinoma
- such cells have stem-like properties & are highly resistant to receptor tyrosine kinase inhibitors such as erlotinib
- in the unbound state, integrin alpha-V/beta-3 recruits KRAS & RalB to the tumor cell plasma membrane, leading to activation of TBK1 & NF-kappaB
More general terms
Component of
References
- ↑ Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 921
- ↑ Clark EA & Brugge JS Integrins and signal transduction pathways: the road taken. Science 268:233 1995 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/7716514
- ↑ <Internet> http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3690
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=ITGB3
- ↑ SHMPD; Note: The Singapore human mutation and polymorphism database http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=ITGB3
- ↑ UniProt http://www.uniprot.org/uniprot/P05106.html