integrin alpha-V/beta-3

Function

• receptor for ADAM23

Structure

• subunits: integrin alpha-V, integrin beta-3

Compartment

membrane Comparative Biology:

• in vitro & in mice, integrin alpha-V/beta-3 is a marker of breast carcinoma, lung carcinoma, & pancreatic carcinoma
  • such cells have stem-like properties & are highly resistant to receptor tyrosine kinase inhibitors such as erlotinib
  • in the unbound state, integrin alpha-V/beta-3 recruits KRAS & RalB to the tumor cell plasma membrane, leading to activation of TBK1 & NF-kappaB

More general terms

• integrin