CD51 (integrin alpha-V, vitronectin receptor alpha chain, ITGAV, MSK8, VNRA)

Function

• integrin alpha-V associates with either
  • integrin beta-1
  • integrin beta-3
  • integrin beta-5
  • integrin beta-6
  • integrin beta-8
• the alpha-V integrins are receptors for
  • vitronectin
  • cytotactin
  • fibronectin
  • fibrinogen
  • laminin
  • matrix metalloproteinase-2
  • osteopontin
  • osteomodulin
  • prothrombin
  • thrombospondin
  • von Willebrand factor
• the alpha-V integrins recognize the sequence R-G-D in a wide array of ligands

Structure

• composed of an heavy & a light chain linked by a disulfide bond
• belongs to the integrin alpha chain family
• contains 7 FG-GAP repeats

Compartment

membrane; Single-pass type 1 membrane protein

Alternative splicing

named isoforms=2

Expression

• platelets
• endothelial cells
• megakaryocytes

Pathology

• interacts with extracellular HIV-1 viral Tat protein
• seems to enhance angiogenesis in Kaposi's sarcoma lesions

More general terms

• integrin-alpha
• CD antigen

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3685
• OMIM: https://mirror.omim.org/entry/193210
• UniProt: http://www.uniprot.org/uniprot/P06756.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3685