thrombospondin
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Function
- following release from platelet alpha granules, thrombospondin complexes with fibrinogen, fibronectin, plasminogen, & histidine-rich glycoprotein, & fibrin when it appears
- one of the characterized complexes is the trimolecular complex of thrombospondin:plasminogen:histidine-rich glycoprotein
- these complexes are formed intercellularly within the platelet aggregate & serve to change the weak intermolecular bridges formed by interaction of fibrinogen & glycoprotein IIb/IIIa into a stronger interplatelet link
More general terms
More specific terms
- thrombospondin-1 (THBS1, TSP, TSP1)
- thrombospondin-2 (THBS2, TSP2)
- thrombospondin-3 (THBS3, TSP3)
- Thrombospondin-4 (THBS4 TSP4)
References
- ↑ Baron M, Norman DG, Campbell ID. Protein modules. Trends Biochem Sci. 1991 Jan;16(1):13-7. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2053133
- ↑ Andrews BS. Is the WKS motif the tissue-factor binding site for coagulation factor VII? Trends Biochem Sci. 1991 Jan;16(1):31-6. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2053135
- ↑ Fibrinolysis, Thrombosis, & Hemostasis: Concepts, Perspectives, and Clinical Applications. S Sherry, Lea & Febiger, Philadelphia, 1992, pg 86