thrombospondin-1 (THBS1, TSP, TSP1)
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Function
- adhesive glycoprotein
- mediates cell-to-cell & cell-to-matrix interactions
- binds heparin
- may play a role in dentinogenesis &/or maintenance of dentin & dental pulp
- ligand for CD36 mediating antiangiogenic properties
- interacts (via the TSP type I repeats) with HRG
- can bind to fibrinogen, fibronectin, laminin, type 5 collagen & integrin alpha-V/beta-1, integrin alpha-V/beta-3 & integrin alpha-IIb/beta-3
- interacts (via the TSP type I repeats) with CD36;
- the interaction conveys an antiangiogenic effect
Structure
- homotrimer; disulfide-linked
- belongs to the thrombospondin family
- contains 3 EGF-like domains
- contains 1 TSP C-terminal (TSPC) domain
- contains 1 TSP N-terminal (TSPN) domain
- contains 3 TSP type-1 domains
- contains 8 TSP type-3 repeats
- contains 1 VWFC domain
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P07996.html
- ↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/THBS1ID42548ch15q15.html